Director, Clinical Science

Director, Clinical Science

Drug development shouldn't be guesswork, not when patients are waiting.

Pathos is building a next-generation biotech with AI at the core. Not as a feature, but as the operating system for how medicines get developed. We believe most drugs don't fail because the science was wrong. They fail because they were tested in the wrong patients, with the wrong assumptions, in trials that couldn't answer the real question: who benefits, and why?

Pathos exists to change that. We're building the largest foundation model in oncology and pairing it with proprietary AI systems, deep oncology expertise, and 200+ petabytes of multimodal data linked to patient outcomes, so we can make development decisions with more precision, much earlier.

This is not theoretical. We're well-capitalized and have the leadership to build a generational company. We invest in and advance our own clinical-stage programs, using our AI platform to sharpen trial design, patient selection and biomarker strategy. So therapies reach the patients most likely to benefit, sooner.

The people who thrive here are operators: deep experts who can specify what needs to happen, orchestrate AI agents to execute at scale, and make high-judgment calls that compound over time. If you have spent your career building and shipping AI systems at scale, this is the environment where that experience becomes a superpower.

The Director, Clinical Science is a hands-on member of the Clinical Development team, responsible for the day-to-day scientific execution of Pathos oncology programs across active Phase 1 and Phase 2 trials. You own protocol development, data review, clinical document authorship, and site-level scientific support from study startup through closeout.

You will work closely with Clinical Operations, Translational Medicine and Biomarker Science to keep studies running with scientific rigor at every step. You will report to the Chief Development Lead.

At Pathos, AI agents handle literature compilation, document formatting, data extraction, and status tracking. That means you spend your time on the science reviewing data, resolving eligibility questions, sharpening protocols, and making the calls that move programs forward, not on administrative overhead.

What You Will Do

• Own protocol development and clinical documents
• Lead data review and monitoring
• Support trial execution and site interactions
• Contribute to regulatory submissions

Who You Are

• MD, PhD or PharmD in a relevant life science discipline required.
• 5 or more years of oncology clinical development experience in biotech or pharma, with direct ownership of protocol design and clinical content authoring.
• Demonstrated track record of delivering study protocols and regulatory documents across Phase 1 and Phase 2 oncology trials.
• Experience in solid tumor oncology; deep familiarity with GCP and applicable regulatory requirements.
• Strong scientific writer with the ability to distill complex evidence into clear, decision relevant documents.

• Experience integrating biomarker and translational strategies into trial design, particularly in genomically defined or molecularly enriched patient populations.
• Comfort working with AI generated analyses, real world evidence, and computational predictions as inputs to scientific and clinical decisions.
• Experience contributing to clinical development plans for multiple concurrent programs in a fast moving organization.
• Familiarity with agentic or AI assisted workflows for document generation, data review, or literature surveillance.

• Experience designing or contributing to adaptive trial designs or platform trials.
• Direct engagement with Health Authorities on oncology programs, including IND and FDA briefing meetings.

Location

The preferred location for this position is in our New York City HQ, though exceptional remote candidates will also be considered.